Umumnya difteri akan menyerang anakanak dalam rentang usia antara 19 tahun, namun ada juga kasus difteri yang terjadi pada remaja dan orang dewasa. Corynebacterium diphtheriae adalah bakteri patogen yang menyebabkan difteri berupa infeksi akut pada saluran pernapasan bagian atas. Morfologi dan patogenitas corynebacterium diphtheriae. Corynebacterium diphtheriae medical microbiology ncbi. Toxic manifestations are uncommon among immunized persons with cutaneous infection 5, 12. Diphtheria is caused by toxigenic strains of the bacteria. Corynebacterium diphtheriae, a grampositive bacillus which is resistant to environmental changes, including freezing. Diphtheria is an acute, toxinmediated disease caused by the bacterium. The best known and most widely studied species is corynebacterium diphtheriae, the causal agent of the disease diphtheria. The site of infection, generally the throat, becomes sore and swollen. Corynebacterium diphtheriae adalah bakteri patogen yang menyebabkan difteri. Corynebacterium diphtheriae wikipedia bahasa indonesia.
Makalah bakteriologi klinik corynebacterium diphtheriae. This photomicrograph shows numerous grampositive asporogenous, rodshaped, corynebacterium diphtheriae bacteria. Habitat and morphology of corynebacterium diphtheriae. A type of bacteria called corynebacterium diphtheriae causes diphtheria. Diphtheria is an infection caused by the bacterium corynebacterium diphtheriae. Diphtheria is transmitted from human contact through respiratory droplets, such as coughing or sneezing. Pengertian eksotoksin corynebacterium diphtheriae adalah eksotoksin dari corynebacterium diphtheriae yang sangat ganas karena dapat meracuni dan merusak berbagai jaringan termasuk jantung, ginjal dan jaringan saraf sehingga menyebabkan kelumpuhan dan kematian. Umumnya difteri akan menyerang anakanak dalam rentang usia antara 19 tahun, namun ada juga kasus. Etiology diphtheria is caused by toxinproducing strains of the bacterium corynebacterium diphtheriae 6.
Diphtheria caused by corynebacterium diphtheriae is potentially one of the most important bacterial diseases. Application of loopmediated isothermal amplification. The laboratory serves as a resource and outbreak support for. Diseased individuals may experience a sore throat, overall weakness, fever, and swollen glands. The disease is caused by diphtheria toxinproducing strains of corynebacterium diphtheriae, corynebacterium ulcerans, and corynebacterium pseudotuberculosis. The disease was described in the 5th century bce by hippocrates, and epidemics were described in the 6th century ad by aetius.
Diphtheria knowledge for medical students and physicians. The name of the disease is derived from the greek diphthera, meaning leather hide. The clinical features of diphtheria are caused by a toxin produced by c. Ia juga dikenal sebagai basil klebsloffler, karena ditemukan pada tahun 1884 oleh bakteriolog jerman, edwin. Diphtheria is an acute infectious disease that is caused by toxinproducing strains of corynebacterium diphtheriae, a grampositive rod. Toxigenic corynebacterium diphtheriae isolated from a.
Also found in mouth, throat, nose, skin and wound of infected person. Corynebacterium diphtheriae respiratory tract infections although inhaled air contains many particles, including microorganisms, the host defense mechanisms in the respiratory tract frequently prevent infection. The toxin inhibits cellular protein synthesis and is responsible for local tissue destruction and pseudomembrane formation 14. Structural basis for the promiscuous pam recognition by. Proteolytic cleavage of the leader sequence from the toxin protein during secretion from the bacterial cell 2. Symptoms often come on fairly gradually, beginning with a sore throat and fever. Found in nasopharynx as well as in skin lesions, which actually represent a reservoir for the spread of diphtheria. Despite the success of mass immunization, which commenced in the 1940s, much remains. Pdf bakteri corynebacterium diphtheriae free download pdf. Difteria adalah suatu penyakit yang disebaban oleh bakteri corynebacterium diphtheriae. Dna templates prepared from bacterial cells fixed with 10% formaldehyde were subjected to a pcr analysis with tox genespecific pcr primers.
Bakteri ini merupakan bakteri batang gram positif tidak membentuk spora. The tox gene of corynebacterium diphtheriae was detected in a formaldehydefixed throat swab taken from a 68yearold man who was reported to have died of suffocation due to a pharyngeal tumor. Most strains require nicotinic and pantothenic acids for growth. Patients carry toxigenic organism upto 3 months after infection. Pada kedua ujungnya bakteri ini memiliki granula metakromatik yang memberi gambaran club shape pada pewarnaan gram. Menurut tingkat keparahannya, penyakit ini dibagi menjadi 3 tingkat yaitu.
It is upper respiratory tract illness and it is a contageous disease 1. Toxin difteri ini, karena mempunyai efek patoligik menyebabkan orang jadi sakit. Cdcs pertussis and diphtheria laboratory provides laboratory support to u. Makalah penyakit difteri corynebacterium diphtheriae. It is a gram positive, nonmotile, non spore forming bacteria. Diphtheria is an upper respiratory tract illness characterized by sore throat, low fever, and an adherent membrane called a pseudomembrane on the tonsils, pharynx, andor nasal cavity. The infection can be transmitted through contact with infected persons and objects that are touched by them. The portals of entry for corynebacterium diphtheriae are the nose, tonsils, and throat. The disease was described in the 5th century bce by hippocrates, and epidemics. Diphtheria is an acute, communicable disease caused by exotoxinproducing corynebacterium diphtheriae. Pdf implication of corynebacterium species in foods.
The condition is typically spread through persontoperson contact or through contact with objects that have the bacteria. L laboratory safety issues l the role of the diagnostic laboratory l the role of, and interaction with, the reference laboratory l procedures for presumptive identification of c. Penyebab penyakit difteri adalah corynebacterium diphtheriae berbentuk batang gram positif, tidak berspora, bercampak atau kapsul. Patients initially present with fever, malaise, and sore throat. Corynebacterium diphtheriae an overview sciencedirect. Infeksi oleh kuman sifatnya tidak invasive, tetapi kuman dapat mengeluarkan toxin, yaitu exotoxin.
Diphtheria is an infectious disease caused by corynebacterium diphtheriae, which is usually transmitted via respiratory droplets. Corynebacterium diphtheriae disease general microscience. However, if there are large numbers of pathogenic organisms within the inspired air or if the host defenses are. Within a few days, a grayish white pseudomembrane develops over the. Corynebacterium diphtheriae este agentul etiologic al difteriei. Corynebacterium diphtheriae is classified into biotypes mitis, intermedius, and gravis according to colony morphology, as well as into lysotypes based upon corynebacteriophage sensitivity. Corynebacterium diphtheriae is a causative agent of diphtheria. Bakteri corynebacterium diphtheriae adalah penyebab penyakit difteri di berbagai belahan dunia. Retrospective diagnosis of diphtheria by detection of the. It is spread by droplets or by contact to susceptible individuals.
Difteri adalah penyakit yang disebabkan oleh kuman corynebacterium diphtheriae, oleh karena itu penyakitnya diberi nama serupa dengan kuman penyebabnya. Immunology and vaccinepreventable diseases pink book. Review of pathology in archived cases and the literature shows that c. Implication of corynebacterium species in foods contamination. Seringkali penyakit ini menyerang dalam bentuk wabah.
1035 573 19 759 265 899 1004 896 1183 634 45 167 697 1215 317 953 112 761 1516 729 1015 1068 821 246 388 1432 501 785 1491 783 485 148 801 1117 1113 1091 907 1196